Faden A I, Vink R, McIntosh T K
Department of Neurology, University of California, San Francisco.
Ann N Y Acad Sci. 1989;553:380-4. doi: 10.1111/j.1749-6632.1989.tb46659.x.
TRH and TRH analogues improve physiological function, survival, and neurological outcome in a variety of models of CNS trauma, including impact spinal cord injury in cats and rats, fluid-percussion-induced brain injury in rats, and compression-induced brain injury in cats. The mechanism by which TRH improves such functions may relate to its ability to improve blood flow and metabolism in the region of injury. Beneficial effects on blood flow may possibly relate to antagonism of the physiological effects of endogenous opioids, leukotrienes, or platelet-activating factor.
促甲状腺激素释放激素（TRH）及其类似物可改善多种中枢神经系统创伤模型中的生理功能、存活率和神经学转归，这些模型包括猫和大鼠的撞击性脊髓损伤、大鼠的液压冲击性脑损伤以及猫的压迫性脑损伤。TRH改善此类功能的机制可能与其改善损伤区域血流和代谢的能力有关。对血流的有益作用可能与拮抗内源性阿片类物质、白三烯或血小板活化因子的生理效应有关。
