Kibler Jeffrey L, Tursich Mischa, Ma Mindy, Malcolm Lydia, Greenbarg Rachel
Jeffrey L Kibler, Lydia Malcolm, Rachel Greenbarg, Center for Psychological Studies, Nova Southeastern University, Ft. Lauderdale, FL 33314, United States.
World J Cardiol. 2014 Jun 26;6(6):455-61. doi: 10.4330/wjc.v6.i6.455.
Posttraumatic stress disorder (PTSD) has been associated with significantly greater incidence of heart disease. Numerous studies have indicated that health problems for individuals with PTSD occur earlier in life than in the general population. Multiple mechanistic pathways have been suggested to explain cardiovascular disese (CVD) risk in PTSD, including neurochemical, behavioral, and immunological changes. The present paper is a review of recent research that examines cardiovascular and immune risk profiles of individuals with PTSD. First, we address the relatively new evidence that the constellation of risk factors commonly experienced in PTSD fits the profile of metabolic syndrome. Next we examine the findings concerning hypertension/blood pressure in particular. The literature on sympathetic and parasympathetic responsivity in PTSD is reviewed. Last, we discuss recent findings concerning immune functioning in PTSD that may have a bearing on the high rates of CVD and other illnesses. Our primary goal is to synthesize the existing literature by examining factors that overlap mechanistically to increase the risk of developing CVD in PTSD.
创伤后应激障碍（PTSD）与心脏病的发病率显著升高有关。大量研究表明，PTSD患者出现健康问题的时间比普通人群更早。人们提出了多种机制途径来解释PTSD患者患心血管疾病（CVD）的风险，包括神经化学、行为和免疫方面的变化。本文是对近期研究的综述，这些研究考察了PTSD患者的心血管和免疫风险状况。首先，我们探讨相对较新的证据，即PTSD患者常见的一系列风险因素符合代谢综合征的特征。接下来我们特别考察有关高血压/血压的研究结果。本文回顾了关于PTSD患者交感神经和副交感神经反应性的文献。最后，我们讨论近期有关PTSD患者免疫功能的研究结果，这些结果可能与CVD及其他疾病的高发病率有关。我们的主要目标是通过考察在机制上相互重叠的因素来综合现有文献，以增加PTSD患者患CVD的风险。
