Castaldo Richard S
Niagara Falls Memorial Medical Center, River Road Primary Care Center, North Tonawanda, NY.
Postgrad Med. 2014 May;126(3):268-73. doi: 10.3810/pgm.2014.05.2775.
Western New York is among the regions with the highest rate of heart disease and stroke in the United States. Multifactorial causes include hypertriglyceridemia and dyslipidemia, and additional therapies may be needed to reduce residual risk that remains even after treatment with statins or other lipid-lowering medications. The purpose of this study was to evaluate the effects of a switch from omega-3 fatty acid ethyl esters (OM3EE) to icosapent ethyl (IPE) on lipid profiles in patients with hyperlipidemia.
This was a retrospective chart review of patient records extracted from multiple medical practices throughout Western New York (4 locations). Randomly selected patients (N = 15) were eligible if they were aged ≥ 18 years with diagnosis codes for high triglyceride (TG) levels or hyperlipidemia and were receiving OM3EE. They were switched from OM3EE to IPE, and lipid parameters were measured after ≥ 2 months.
The records of 15 patients were analyzed and lipid measurements were available for 14 patients; 10 were on statins and 4 were on ezetimibe. At ≥ 2 months after the switch to IPE, 13 patients experienced decreases in total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) levels; 12 experienced a decrease in TG and low-density lipoprotein cholesterol (LDL-C) levels; and changes in HDL-C levels were varied, with no change in 1 patient, decreases in 9 patients, and increases in 4 patients.
The results of this real-world retrospective analysis of 14 patients with hyperlipidemia demonstrated reductions in TG, LDL-C, TC, and non-HDL-C levels, with mixed results in HDL-C levels, after switching from OM3EE to IPE.
纽约西部是美国心脏病和中风发病率最高的地区之一。多因素病因包括高甘油三酯血症和血脂异常，即使在使用他汀类药物或其他降脂药物治疗后，可能仍需要额外的治疗来降低残留风险。本研究的目的是评估从ω-3脂肪酸乙酯（OM3EE）转换为二十碳五烯酸乙酯（IPE）对高脂血症患者血脂谱的影响。
这是一项对从纽约西部多个医疗诊所（4个地点）提取的患者记录进行的回顾性图表审查。随机选择的患者（N = 15）符合条件，年龄≥18岁，有高甘油三酯（TG）水平或高脂血症的诊断代码，且正在接受OM3EE治疗。他们从OM3EE转换为IPE，并在≥2个月后测量血脂参数。
分析了15例患者的记录，14例患者有血脂测量数据；10例患者服用他汀类药物，4例患者服用依折麦布。转换为IPE后≥2个月时，13例患者的总胆固醇（TC）和非高密度脂蛋白胆固醇（非HDL-C）水平下降；12例患者的TG和低密度脂蛋白胆固醇（LDL-C）水平下降；高密度脂蛋白胆固醇（HDL-C）水平变化各异，1例患者无变化，9例患者下降，4例患者上升。
这项对14例高脂血症患者的真实世界回顾性分析结果表明，从OM3EE转换为IPE后，TG、LDL-C、TC和非HDL-C水平降低，HDL-C水平结果不一。
