Derache Anne-Flore, Rocourt Nathalie, Delattre Claire, Vinchon Matthieu, Orbach Daniel, Leblond Pierre
Centre Oscar-Lambret, Unité d'oncologie pédiatrique, 3, rue Frédéric-Combemale, 59000 Lille, France.
Centre Oscar-Lambret, Département d'imagerie médicale, Lille, France.
Bull Cancer. 2014 Jun;101(6):626-36. doi: 10.1684/bdc.2014.1985.
Melanotic Neuroectodermal Tumors of Infancy (MNTI), also known as melanotic progonoma are rare tumors affecting young children. The main locations are primarily head, neck and cranial vault. Complete surgical resection remains the standard treatment for these tumors leading to healing in the majority of cases. However, recurrent, metastatic or locally advanced forms require other treatments. The literature since 1980 reported 27 cases of patients who received treatment with chemotherapy and/or radiation therapy. Among the 24 patients who received chemotherapy, a reduction or stabilization of tumor volume was observed in 14 observations. Nine patients received radiation therapy and one patient experiences a tumor improvement. The information provided by this review can evoke the chemosensitivity of this rare tumor type but are insufficient to conclude about their radiosensitivity.
婴儿黑色素性神经外胚层肿瘤（MNTI），也称为黑色素性原细胞瘤，是一种罕见的影响幼儿的肿瘤。主要部位主要是头部、颈部和颅顶。完整的手术切除仍然是这些肿瘤的标准治疗方法，大多数情况下可实现治愈。然而，复发、转移或局部晚期形式需要其他治疗方法。自1980年以来的文献报道了27例接受化疗和/或放疗的患者。在接受化疗的24例患者中，14例观察到肿瘤体积缩小或稳定。9例患者接受了放疗，1例患者肿瘤有所改善。本综述提供的信息可以唤起对这种罕见肿瘤类型的化学敏感性，但不足以得出其放射敏感性的结论。
