Pernice W, Schuchmann L, Dippell J, Suschke J, Vogel P, Truckenbrodt H, Schindera F, Humburg C, Brzoska J
Department of Pediatrics, University of Freiburg, Federal Republic of Germany.
Arthritis Rheum. 1989 May;32(5):643-6. doi: 10.1002/anr.1780320520.
Nine severely ill patients with a confirmed diagnosis of systemic juvenile rheumatoid arthritis were treated with recombinant gamma-interferon (gamma-IFN) in addition to the therapy they were previously receiving for their disease. Improvements in clinical symptoms were noted in 7 of the patients, and median laboratory values also showed a marked improvement after gamma-IFN treatment. A relapse occurred in 1 patient. The results of this study should stimulate further research on the use of gamma-IFN in systemic juvenile rheumatoid arthritis, particularly in determining the appropriate effective dosage.
9例确诊为全身型幼年类风湿关节炎的重症患者，在接受原有疾病治疗的基础上，加用重组γ干扰素（γ-IFN）进行治疗。7例患者的临床症状有改善，γ-IFN治疗后实验室指标中位数也显示出明显改善。1例患者出现复发。本研究结果应能推动对γ-IFN在全身型幼年类风湿关节炎中应用的进一步研究，尤其是确定合适的有效剂量。
