Badgaiyan Rajendra D, Weise Steven, Wack David S, Vidal Melo Marcos F
From the Department of Psychiatry, State University of New York at Buffalo, Buffalo, New York; †Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts; ‡Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, New York; and §Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Anesth Analg. 2014 Sep;119(3):550-553. doi: 10.1213/ANE.0000000000000334.
Reports of memory impairment after cardiac surgery are controversial. To address this controversy, we used positron emission tomography to examine changes in regional cerebral blood flow (rCBF) during memory processing before and after elective coronary artery bypass grafting surgery. In postoperative scans, we observed significantly reduced rCBF in 2 of the most important memory processing areas: the medial temporal lobe (P = 0.023) and the prefrontal cortex (P = 0.002). The results suggest postoperative attenuation of rCBF in brain areas involved in memory processing. These reductions could be used to evaluate severity of memory impairment after coronary artery bypass grafting surgery in patients at risk.
心脏手术后出现记忆障碍的报道存在争议。为了解决这一争议，我们使用正电子发射断层扫描技术来检测择期冠状动脉搭桥手术后记忆处理过程中局部脑血流量（rCBF）的变化。在术后扫描中，我们观察到在两个最重要的记忆处理区域，即内侧颞叶（P = 0.023）和前额叶皮质（P = 0.002），rCBF显著降低。结果表明，参与记忆处理的脑区术后rCBF减弱。这些降低情况可用于评估有风险的患者冠状动脉搭桥手术后记忆障碍的严重程度。
