Takaya Yoshiaki, Hotta Rie, Fujiwara Kenshu, Otani Risa, Uchiyama Yurika, Sakakibara Mizuki, Fukuda Eri, Niwa Masatake, Inouye Kei, Oohata Akiko A
Faculty of Pharmacy, Meijo University , Nagoya 468-8503, Japan.
Org Lett. 2014 Jul 18;16(14):3660-3. doi: 10.1021/ol5014119. Epub 2014 Jun 30.
The structure of the prespore-cell-promoting factor from Dictyostelium discoideum was determined to be 2-hydroxy-5-methyl-6-pentylbenzoquinone. The synthetic compound has prespore-cell-promoting activity similar to the natural one, with half-maximal induction at a concentration as low as 40 pM. It was also found that the factor induces aggregation in an aggregation-deficient mutant of a related species, Polysphodilium violaceum. Both these activities are sensitive to positional isomerism with the 6-methyl-5-pentyl isomer showing no detectable activity.
已确定盘基网柄菌的前孢子细胞促进因子的结构为2-羟基-5-甲基-6-戊基苯醌。该合成化合物具有与天然化合物相似的前孢子细胞促进活性，在低至40 pM的浓度下诱导半数最大反应。还发现该因子能在相关物种紫多盘菌的聚集缺陷型突变体中诱导聚集。这两种活性对位置异构敏感，6-甲基-5-戊基异构体没有可检测到的活性。
