18F-氟来他胺 PET/CT 能否显示心脏淀粉样变性？
Is 18F-flutemetamol PET/CT able to reveal cardiac amyloidosis?
机构信息
From the Departments of *Nuclear Medicine, †Pathology, ‡Neurology, §Hematology, and ¶Cardiology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
出版信息
Clin Nucl Med. 2014 Aug;39(8):747-9. doi: 10.1097/RLU.0000000000000492.
We report here the case of a 56-year-old man with well-documented cardiac light chain amyloidosis successfully imaged with F-flutemetamol PET/CT in 2011. A matched pair healthy volunteer was imaged in the same conditions, and no specific heart uptake could be detected. The present report suggests the potential benefit of this new pharmaceutical in this indication, as it has been recently reported for C-Pittsburgh compound B, but with the main advantage to benefit from the more practical half-life of F. Further prospective trials would, however, be required to define the potential impact of F-flutemetamol PET/CT in cardiac amyloidosis.
我们在此报告一例 56 岁男性患者的病例，该患者于 2011 年成功接受 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-flutemetamol PET/CT）检查，该患者的心脏轻链淀粉样变性有明确的记录。以相同的条件对一对匹配的健康志愿者进行了成像，未检测到特定的心脏摄取。本报告提示了这种新药物在该适应证中的潜在益处，因为最近已报告 C-Pittsburgh 化合物 B 具有相同的益处，但 F 的半衰期更实用，这是主要优势。然而，需要进一步的前瞻性试验来确定 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在心脏淀粉样变性中的潜在影响。
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