To live with normal GFR: when higher is not better.

Eriksen et al. unmask an independent link between a high glomerular filtration rate (GFR) and subclinical cardiovascular damage in a large cohort of nondiabetic middle-aged people in Tromsø, Norway. Although others have previously reported an association between estimated GFR and cardiovascular risk factors, the present work is remarkable in that it relies on measured GFR, thus overcoming potential bias of the limited accuracy of common GFR estimates in individuals with high GFR values.