Demır Kenan, Avcı Ahmet, Yılmaz Sema, Demır Tarık, Ersecgın Ahmet, Altunkeser Bulent Behlul
Department of Cardiology, Faculty of Medicine, Selcuk University , Konya , Turkey.
Scand Cardiovasc J. 2014 Aug;48(4):197-201. doi: 10.3109/14017431.2014.935801. Epub 2014 Jul 18.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a variety of clinical features. Cardiac involvement is present in more than half of the patients with SLE. Fragmentation of QRS (fQRS) is presumed marker of cardiovascular risk and has not been previously evaluated in SLE.
A total of 56 women previously diagnosed with SLE were recruited. In addition, a control group consisting of 51 healthy people was formed. QRS complexes were also evaluated in terms of fragmentations. All patients with SLE and control subjects underwent transthoracic echocardiographic examination. Erythrocyte sedimentation rate and C-reactive protein levels were also obtained.
Frequency of fQRS was higher in patients with SLE (41% vs. 21%, p = 0.03). Left ventricular posterior wall thickness and mass index were higher in the patients with SLE. CRP levels and age were significantly higher, and disease duration was significantly longer in the fQRS(+) group (p = 0.02, 0.01, and 0.006, respectively).
A careful cardiovascular evaluation and follow-up is essential to continuously improve survival in SLE. For this purpose, fQRS may be used for the early detection in patients with SLE.
系统性红斑狼疮（SLE）是一种具有多种临床特征的系统性自身免疫性疾病。超过半数的SLE患者存在心脏受累情况。QRS波碎裂（fQRS）被认为是心血管风险的标志物，此前尚未在SLE中进行评估。
共招募了56名先前诊断为SLE的女性。此外，组建了一个由51名健康人组成的对照组。还对QRS波群的碎裂情况进行了评估。所有SLE患者和对照受试者均接受了经胸超声心动图检查。还获取了红细胞沉降率和C反应蛋白水平。
SLE患者中fQRS的发生率更高（41%对21%，p = 0.03）。SLE患者的左心室后壁厚度和质量指数更高。fQRS（+）组的CRP水平和年龄显著更高，病程显著更长（分别为p = 0.02、0.01和0.006）。
仔细的心血管评估和随访对于持续提高SLE患者的生存率至关重要。为此，fQRS可用于SLE患者的早期检测。
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