Grosse Ulrich, Hetzel Jörg, Gündel Lutz, Gatidis Sergios, Syha Roland, Schabel Christoph, Springer Fabian, Horger Marius
From the *Diagnostic and Interventional Radiology and †Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen; and ‡Computed Tomography, Siemens Medical Solutions, Forchheim, Germany.
J Comput Assist Tomogr. 2014 Sep-Oct;38(5):779-85. doi: 10.1097/RCT.0000000000000121.
The aim of this study was to objectify changes in volume and density of treated and untreated pulmonary lobes following endobronchial coiling for lung volume reduction by comparison with clinical (6-m walk test) and pulmonary function tests.
Twenty-two lobes in 17 patients (8 men, 9 women) were treated by endobronchial coiling and underwent preinterventional and postinterventional computed tomography examinations (inspiratory and expiratory phase) as well as pulmonary function test measurements.
Responders (n = 14) presented a significant increase (70 ± 11 m) in the walking distance (6-m walk test) and FEV1 (forced expiratory volume in 1 second) values (61 ± 21 mL). Only in responders inspiratory volume (VolIn) of the target lobe significantly decreased (10.0% ± 16.4%; P = 0.0245), and VolIn of the nontreated ipsilateral lobe significantly increased (5.5% ± 9.1%; P = 0.0209).
Our results objectify volume reduction of the treated lobe coupled by a significant volume expansion of the ipsilateral lobe as a sole correlate for clinical improvement in responders.
本研究的目的是通过与临床（6分钟步行试验）和肺功能测试相比较，客观评估经支气管内圈套术进行肺减容后，治疗侧和未治疗侧肺叶的体积和密度变化。
对17例患者（8例男性，9例女性）的22个肺叶进行支气管内圈套术治疗，并在介入治疗前和介入治疗后进行计算机断层扫描检查（吸气期和呼气期）以及肺功能测试。
反应者（n = 14）的步行距离（6分钟步行试验）和第1秒用力呼气量（FEV1）值（61±21 mL）显著增加（70±11 m）。仅在反应者中，目标肺叶的吸气容积（VolIn）显著降低（10.0%±16.4%；P = 0.0245），同侧未治疗肺叶的VolIn显著增加（5.5%±9.1%；P = 0.0209）。
我们的结果客观显示，治疗侧肺叶体积减小，同时同侧肺叶显著扩张，这是反应者临床改善的唯一相关因素。
