Salamunić Ilza, Kaliterna Dusanka Martinović
Reumatizam. 2013;60(2):39-42.
The antineutrophil cytoplasmic antibody (ANCA) are associated with distinct forms of primary small vessel vasculitides, collectively reffered to as ANCA-associated vasculitis (AAV). ANCA were originally identified by IIF. Importantly, however, only ANCA directed to PR3 (PR3-ANCA) or MPO (MPO-ANCA) are relevant for the diagnosis AAV, there is international consensus that ANCA should be detected by a combination of IIF and antigen-specific assays, i.e. detection of PR3 and MPO-ANCA. Several novel technologies have become available for antigen-specific ANCA detection.
抗中性粒细胞胞浆抗体（ANCA）与原发性小血管炎的不同形式相关，统称为ANCA相关性血管炎（AAV）。ANCA最初是通过间接免疫荧光法（IIF）鉴定出来的。然而，重要的是，只有针对蛋白酶3（PR3-ANCA）或髓过氧化物酶（MPO-ANCA）的ANCA与AAV的诊断相关，国际上一致认为应通过IIF和抗原特异性检测相结合的方法来检测ANCA，即检测PR3和MPO-ANCA。已经有几种新技术可用于抗原特异性ANCA检测。
