Song S, Chen J K, He M L, Fotherby K
Institute of Planned Parenthood Research, Shanghai, China.
Contraception. 1989 Apr;39(4):385-99. doi: 10.1016/0010-7824(89)90117-0.
Serum SHBG and ceruloplasmin (CP) concentrations were measured in women throughout a cycle of treatment with four oral contraceptives. In women receiving 150 micrograms levonorgestrel (LNG) daily both SHBG and CP decreased. SHBG also decreased, but CP increased, in women receiving ethynyloestradiol (EE) 30 micrograms with LNG 150 micrograms. In women taking 35 micrograms EE with either 600 micrograms or 1000 micrograms norethisterone, increases in CP were similar but SHBG increased more with the lower dose. Serum concentrations had not returned to pretreatment levels by eight days after cessation of dosing. The findings are compared with similar results for women taking 30 micrograms or 50 micrograms EE or an EE,LNG triphasic formulation. Serum concentrations of the gestagens were also measured. Increases in these concentrations when the gestagen was administered with EE to levels higher than expected from administration of the gestagen alone cannot be explained by increased binding to SHBG but are more likely to be due to changes in their metabolism. Differences in the responses of ostensibly closely related proteins of hepatic origin such as SHBG and CP to the oral contraceptives demonstrate that neither can be extrapolated to other pharmacodynamic responses.
在使用四种口服避孕药进行治疗的整个周期中，对女性的血清性激素结合球蛋白（SHBG）和铜蓝蛋白（CP）浓度进行了测量。每日服用150微克左炔诺孕酮（LNG）的女性，SHBG和CP均下降。服用30微克炔雌醇（EE）和150微克LNG的女性，SHBG下降，但CP升高。服用35微克EE与600微克或1000微克炔诺酮的女性，CP升高相似，但较低剂量时SHBG升高更多。停药8天后血清浓度尚未恢复到治疗前水平。将这些结果与服用30微克或50微克EE或EE-LNG三相制剂的女性的类似结果进行了比较。还测量了孕激素的血清浓度。当孕激素与EE一起给药时，其浓度升高至高于单独给予孕激素时预期的水平，这不能用与SHBG结合增加来解释，而更可能是由于其代谢变化。肝脏来源的表面上密切相关的蛋白质（如SHBG和CP）对口服避孕药的反应差异表明，两者都不能外推到其他药效学反应。
