Shin S J, Taniguchi H, Hara Y, Ejiri K, Morimoto Y, Yamashiro Y, Ishida Y, Kuroda N, Ishihara K, Tsai J H
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Diabetes Res Clin Pract. 1989 Apr 1;6(3):167-71. doi: 10.1016/0168-8227(89)90025-9.
We studied the effects of a hydroxyl radical scavenger, dimethylthiourea (DMTU), on syngeneic islet grafts. Six hundred fresh islets taken from two Wistar rats were transplanted intraportally into other Wistar rats made diabetic with streptozotocin. DMTU was given to five recipients intraperitoneally for a month while nine controls received only intraperitoneal saline. The DMTU-treated group had significantly lower fasting plasma glucose levels at 1.5, 4.5, 5, 5.5, 6, 7, 9 and 11 weeks and had higher mean fasting body weights between the 2.5th week and their eventual sacrifice. Their islets also survived significantly longer than did those of the controls (73.6 +/- 3.4 vs. 21.6 +/- 9.4 days). This suggests that oxygen free radical production endangers graft survival and that the hydroxyl radical scavenger DMTU protects syngeneic islet grafts.
我们研究了羟自由基清除剂二甲基硫脲（DMTU）对同基因胰岛移植的影响。从两只Wistar大鼠获取的600个新鲜胰岛经门静脉移植到另外用链脲佐菌素诱导糖尿病的Wistar大鼠体内。五只受体大鼠腹腔注射DMTU，持续一个月，而九只对照大鼠仅腹腔注射生理盐水。DMTU处理组在第1.5、4.5、5、5.5、6、7、9和11周时空腹血糖水平显著更低，且在第2.5周及其最终处死之间平均空腹体重更高。其胰岛存活时间也显著长于对照组（73.6±3.4天对21.6±9.4天）。这表明氧自由基的产生危及移植存活，且羟自由基清除剂DMTU可保护同基因胰岛移植。
