Fitzmaurice Gerard J, McWilliams Billy, Nölke Lars, Redmond J Mark, McGuinness Jonathan G, O'Donnell Mark E
Department of Cardiothoracic Surgery, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland; Department of Anaesthetics, Intensive Care & Pain Medicine, School of Medicine, Cardiff University, Cardiff, Wales.
Department of Anaesthetics, Intensive Care & Pain Medicine, School of Medicine, Cardiff University, Cardiff, Wales.
Ann Thorac Surg. 2014 Aug;98(2):756-64. doi: 10.1016/j.athoracsur.2014.02.089. Epub 2014 Jun 28.
Cardiac surgical patients often have associated comorbidities that can impede normal wound healing; however, statin therapy has the potential to improve this process through augmentation of the normal inflammatory response. Outcomes included a 30% earlier rate of wound epithelialization and an 80% greater wound-breaking strength combined with faster wound healing rates (13.0 days vs 18.7 days, p<0.0001). Inhibition of farnesyl pyrophosphate may hold a key role in the mediation of such advantageous effects. This systematic review suggests that there is sufficient evidence to warrant completion of a human trial to assess the effects of statins on wound healing.
心脏外科手术患者常常伴有能妨碍正常伤口愈合的合并症；然而，他汀类药物疗法有潜力通过增强正常炎症反应来改善这一过程。结果包括伤口上皮形成率提前30%，伤口抗裂强度提高80%，同时伤口愈合速度加快（13.0天对18.7天，p<0.0001）。法尼基焦磷酸的抑制作用可能在介导这些有利效应中起关键作用。本系统评价表明，有足够证据保证开展一项人体试验来评估他汀类药物对伤口愈合的影响。
