Vorum H, Andersen S, Brodersen R
Institute of Medical Biochemistry, University of Aarhus, Denmark.
Epilepsia. 1989 May-Jun;30(3):370-3. doi: 10.1111/j.1528-1157.1989.tb05311.x.
Addition of sodium valproate (VPA) to a buffered solution of human serum albumin (HSA) or to serum reduces binding affinity for palmitate. A maximal pharmacologic VPA concentration, 700 microM, added to a 300-microM albumin solution, reduces the reserve albumin concentration for binding of palmitate by a factor of 0.64. One possible site model explaining these findings may be that VPA competes strongly with one among three palmitate molecules, bound to albumin with high affinity, and induces a weaker displacement of a second palmitate.
