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[碳酸锂在人类急性放射病中作为白细胞刺激剂的应用]

[Use of lithium carbonate as a leukocyte stimulant in acute radiation sickness in humans].

作者信息

Konchalovskiĭ M V, Shishkova T V, Chotiĭ V G, Baranov A E

出版信息

Gematol Transfuziol. 1989 Mar;34(3):16-23.

PMID:2498149
Abstract

A total of 50 patients, who had suffered from acute radiation sickness (I-III degree of severity) as a result of the accident at the Chernobyl Nuclear Power Plant, were followed up for hematological changes. The absorbed dose of relatively even gamma-irradiation assessed by karyometry fluctuated from 0.5 to 5.7 Gy. In 17 of the patients the influence of lithium carbonate on the course of radiation neutropenia was evaluated. No appreciable effect of the agent administration in a dose of 900 mg/patient/day was recorder from 9 to 42 day after irradiation. The authors have also considered the correlations of the values of irradiation doses calculated by varying methods of biological dosimetry.

摘要

共有50名因切尔诺贝利核电站事故而遭受急性放射病(Ⅰ - Ⅲ度严重程度)的患者接受了血液学变化随访。通过核仁测量法评估的相对均匀γ辐射吸收剂量在0.5至5.7 Gy之间波动。对其中17名患者评估了碳酸锂对放射性中性粒细胞减少病程的影响。在照射后9至42天,未记录到以900毫克/患者/天的剂量给药该药物有明显效果。作者还考虑了通过不同生物剂量测定方法计算的照射剂量值之间的相关性。

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