用于评估转化研究中基因治疗的影像学研究。

Imaging studies for evaluating gene therapy in translational research.

作者信息

Peñuelas Iván, Gambhir Sanjiv S

机构信息

MicroPET Research Unit, CIMA-CUN, University of Navarra, Pamplona, Spain.

Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University, Stanford, CA, USA.

出版信息

Drug Discov Today Technol. 2005 Winter;2(4):335-43. doi: 10.1016/j.ddtec.2005.11.006.

DOI:10.1016/j.ddtec.2005.11.006

PMID:24982010

Abstract

Molecular imaging of gene expression in living subjects is leading to significant advances in the field of gene therapy. Three different technologies have been utilized for monitoring gene expression: optical imaging, radionuclide imaging and magnetic resonance imaging. In the present review, we focus on the latest developments including multimodality approaches and recent imaging of human gene therapy to noninvasively determine the location(s), magnitude and time-variation of gene therapy. Continued development should lead to greater use of these technologies in gene therapy and also help to shed light towards optimizing gene therapy in preclinical models and in the clinical setting.:

摘要

对活体受试者的基因表达进行分子成像正推动着基因治疗领域取得重大进展。已采用三种不同技术来监测基因表达：光学成像、放射性核素成像和磁共振成像。在本综述中，我们重点关注最新进展，包括多模态方法以及近期对人类基因治疗的成像，以无创地确定基因治疗的位置、程度和时间变化。持续的发展应会促使这些技术在基因治疗中得到更广泛应用，并有助于为在临床前模型和临床环境中优化基因治疗提供思路。