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Biomarkers Beyond the Natriuretic Peptides for Chronic Heart Failure: Galectin-3 and Soluble ST2.慢性心力衰竭中除利钠肽之外的生物标志物:半乳糖凝集素-3和可溶性ST2
EJIFCC. 2012 Oct 12;23(3):98-102. eCollection 2012 Oct.
2
Worsening renal function during renin-angiotensin-aldosterone system inhibitor initiation and long-term outcomes in patients with left ventricular systolic dysfunction.起始使用肾素-血管紧张素-醛固酮系统抑制剂期间肾功能恶化与左心室收缩功能障碍患者的长期结局。
Eur J Heart Fail. 2014 Jan;16(1):41-8. doi: 10.1002/ejhf.13. Epub 2013 Dec 11.
3
Proteinuria and its relation to cardiovascular disease.蛋白尿及其与心血管疾病的关系。
Int J Nephrol Renovasc Dis. 2013 Dec 21;7:13-24. doi: 10.2147/IJNRD.S40522.
4
Prognostic value of plasma neutrophil gelatinase-associated lipocalin for mortality in patients with heart failure.血浆中性粒细胞明胶酶相关载脂蛋白对心力衰竭患者死亡率的预测价值。
Circ Heart Fail. 2014 Jan;7(1):35-42. doi: 10.1161/CIRCHEARTFAILURE.113.000242. Epub 2013 Dec 17.
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Hypomagnesaemia in patients hospitalised in internal medicine is associated with increased mortality.内科住院患者的低镁血症与死亡率增加有关。
Int J Clin Pract. 2014 Jan;68(1):111-6. doi: 10.1111/ijcp.12260.
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Correlation between iron stores and QTc dispersion in chronic ambulatory peritoneal dialysis patients.慢性非卧床腹膜透析患者铁储备与QTc离散度的相关性
Ren Fail. 2014 Mar;36(2):187-90. doi: 10.3109/0886022X.2013.836750. Epub 2013 Sep 24.
7
Cardiovascular disease in patients with chronic kidney disease.慢性肾病患者的心血管疾病
Nephrology (Carlton). 2014 Jan;19(1):3-10. doi: 10.1111/nep.12148.
8
Prevalence of ventricular arrhythmia and its associated factors in nondialyzed chronic kidney disease patients.非透析慢性肾脏病患者室性心律失常的患病率及其相关因素。
PLoS One. 2013 Jun 7;8(6):e66036. doi: 10.1371/journal.pone.0066036. Print 2013.
9
Additive value of blood neutrophil gelatinase-associated lipocalin to clinical judgement in acute kidney injury diagnosis and mortality prediction in patients hospitalized from the emergency department.血液中性粒细胞明胶酶相关脂质运载蛋白在急诊科住院患者急性肾损伤诊断及死亡率预测中对临床判断的附加价值。
Crit Care. 2013 Feb 12;17(1):R29. doi: 10.1186/cc12510.
10
Heart rate variability and renal organ damage in hypertensive patients.高血压患者的心率变异性与肾器官损害
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:3825-8. doi: 10.1109/EMBC.2012.6346801.

肾衰竭中心室心律失常风险的实验室标志物。

Laboratory markers of ventricular arrhythmia risk in renal failure.

作者信息

Mozos Ioana

机构信息

Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, T. Vladimirescu Street 14, 300173 Timisoara, Romania.

出版信息

Biomed Res Int. 2014;2014:509204. doi: 10.1155/2014/509204. Epub 2014 May 26.

DOI:10.1155/2014/509204
PMID:24982887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4058221/
Abstract

Sudden cardiac death continues to be a major public health problem. Ventricular arrhythmia is a main cause of sudden cardiac death. The present review addresses the links between renal function tests, several laboratory markers, and ventricular arrhythmia risk in patients with renal disease, undergoing or not hemodialysis or renal transplant, focusing on recent clinical studies. Therapy of hypokalemia, hypocalcemia, and hypomagnesemia should be an emergency and performed simultaneously under electrocardiographic monitoring in patients with renal failure. Serum phosphates and iron, PTH level, renal function, hemoglobin and hematocrit, pH, inflammatory markers, proteinuria and microalbuminuria, and osmolarity should be monitored, besides standard 12-lead ECG, in order to prevent ventricular arrhythmia and sudden cardiac death.

摘要

心脏性猝死仍然是一个主要的公共卫生问题。室性心律失常是心脏性猝死的主要原因。本综述探讨了肾功能检查、几种实验室指标与肾病患者(无论是否接受血液透析或肾移植)室性心律失常风险之间的联系,重点关注近期的临床研究。对于肾衰竭患者,低钾血症、低钙血症和低镁血症的治疗应作为紧急情况,并在心电图监测下同时进行。除标准12导联心电图外,还应监测血清磷酸盐和铁、甲状旁腺激素水平、肾功能、血红蛋白和血细胞比容、pH值、炎症标志物、蛋白尿和微量白蛋白尿以及渗透压,以预防室性心律失常和心脏性猝死。