普通青少年人群中单纯疱疹病毒1型暴露与认知功能之间的关联。TRAILS研究。
Association between exposure to HSV1 and cognitive functioning in a general population of adolescents. The TRAILS study.
作者信息
Jonker Iris, Klein Hans C, Duivis Hester E, Yolken Robert H, Rosmalen Judith G M, Schoevers Robert A
机构信息
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center for Psychopathology and Emotion regulation (ICPE), Groningen, The Netherlands.
Center of Research on Psychology in Somatic Diseases, Department of Medical and Neuropsychology, Tilburg University, Tilburg, The Netherlands.
出版信息
PLoS One. 2014 Jul 1;9(7):e101549. doi: 10.1371/journal.pone.0101549. eCollection 2014.
BACKGROUND
Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population.
METHODS
This study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use.
RESULTS
Presence of HSV1 antibodies was associated with memory function ((B = -0.272, 95% CI = -0.556 to -0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is -0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = -0.160, 95% CI = -0.280 to -0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning.
CONCLUSIONS
Both presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.
背景
不同疱疹病毒感染与精神病患者及健康成年人的认知功能有关。本研究的目的是探究在普通青少年人群中，不同疱疹病毒抗体是否与认知功能存在前瞻性关联。
方法
本研究在追踪青少年生活方式与健康轨迹（TRAILS）队列中进行，这是一个大型前瞻性普通人群队列（N = 1084，女性占54%，平均年龄16.2岁（标准差0.6））。在16岁时，除了测量高敏C反应蛋白（hsCRP）外，还检测了针对单纯疱疹病毒1型（HSV1）、单纯疱疹病毒2型（HSV2）、巨细胞病毒（CMV）和EB病毒（EBV）的免疫球蛋白G抗体。两年后，使用15词任务和自我排序指认任务评估即时记忆和执行功能。采用带有自抽样法的多元线性回归分析来研究病毒感染与认知功能之间的关联，并对性别、社会经济地位、种族和大麻使用情况进行了校正。
结果
HSV1抗体的存在与记忆功能相关（B = -0.272，95%置信区间 = -0.556至-0.016，p = 0.047），而与执行功能的关联未达到统计学显著性（B = 0.560，95%置信区间为-0.053至1.184，p = 0.075）。HSV1抗体水平与记忆功能（B = -0.160，95%置信区间 = -0.280至-0.039，p = 0.014）和执行功能（B = 0.296，95%置信区间 = 0.011至0.578，p = 0.046）均相关。其他疱疹病毒和hsCRP与认知功能无关。
结论
在一大群青少年中，HSV1抗体的存在和水平均与认知能力下降存在前瞻性关联。
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