Masuda M, Takanashi M, Motoji T, Oshimi K, Mizoguchi H
Department of Medicine, Tokyo Women's Medical College, Japan.
Int J Cell Cloning. 1989 Mar;7(2):120-8. doi: 10.1002/stem.5530070206.
The effects of recombinant interferons (rIFNs) on colony formation by progenitor cells from the peripheral blood of patients with hairy cell leukemia (HCL) were examined. Results showed that both rIFN-alpha and -beta inhibited HCL colony formation in a dose-dependent manner, with the inhibitory effect of rIFN-alpha being similar in degree with that of rIFN-beta. The inhibitory effect of rIFN-gamma, however, was not uniform; of four patients, inhibition was observed in cells from two patients, but no effect was found in the cells of the other two. These results indicate that rIFN-alpha and -beta could be effective in the treatment of HCL, whereas rIFN-gamma may be of limited efficacy.
研究了重组干扰素（rIFNs）对毛细胞白血病（HCL）患者外周血祖细胞集落形成的影响。结果显示，rIFN-α和rIFN-β均以剂量依赖方式抑制HCL集落形成，rIFN-α的抑制作用程度与rIFN-β相似。然而，rIFN-γ的抑制作用并不一致；在4例患者中，2例患者的细胞出现抑制，而另外2例患者的细胞未发现有影响。这些结果表明，rIFN-α和rIFN-β可能对HCL治疗有效，而rIFN-γ的疗效可能有限。
