Effect of recombinant interferons on hairy cell leukemia progenitors.
作者信息
Masuda M, Takanashi M, Motoji T, Oshimi K, Mizoguchi H
机构信息
Department of Medicine, Tokyo Women's Medical College, Japan.
出版信息
Int J Cell Cloning. 1989 Mar;7(2):120-8. doi: 10.1002/stem.5530070206.
The effects of recombinant interferons (rIFNs) on colony formation by progenitor cells from the peripheral blood of patients with hairy cell leukemia (HCL) were examined. Results showed that both rIFN-alpha and -beta inhibited HCL colony formation in a dose-dependent manner, with the inhibitory effect of rIFN-alpha being similar in degree with that of rIFN-beta. The inhibitory effect of rIFN-gamma, however, was not uniform; of four patients, inhibition was observed in cells from two patients, but no effect was found in the cells of the other two. These results indicate that rIFN-alpha and -beta could be effective in the treatment of HCL, whereas rIFN-gamma may be of limited efficacy.
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