de Oliveira Poswar Fabiano, de Carvalho Fraga Carlos Alberto, Gomes Emisael Stênio Batista, Farias Lucyana Conceição, Souza Linton Wallis Figueiredo, Santos Sérgio Henrique Souza, Gomez Ricardo Santiago, de-Paula Alfredo Maurício Batista, Guimarães André Luiz Sena
Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Int J Surg Pathol. 2015 Feb;23(1):20-5. doi: 10.1177/1066896914540998. Epub 2014 Jun 30.
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P < .05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.
鳞状细胞癌（SCC）和基底细胞癌（BCC）是两种具有不同侵袭和转移潜能的皮肤肿瘤。光化性角化病（AK）是SCC的前驱病变。对29例BCC、12例SCC和13例AK样本进行免疫组织化学检测，以评估基质金属蛋白酶-2（MMP-2）和膜型基质金属蛋白酶-1（MT1-MMP）的表达。用阳性细胞与总细胞的比例对染色进行定量分析。P < 0.05水平被视为具有统计学意义。我们发现，与BCC相比，SCC的肿瘤基质和实质中MMP-2的表达更高。该蛋白在SCC及其前驱病变光化性角化病中的表达也相似，与低风险BCC相比，高风险BCC基质中的表达更高。作为MMP-2激活剂的MT1-MMP在所有组中的表达相似。我们的结果表明，MMP-2表达可能导致SCC和BCC中出现不同的侵袭模式。
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