Moran D B, Ziegler C B, Dunne T S, Kuck N A, Lin Y I
American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
J Med Chem. 1989 Jun;32(6):1313-8. doi: 10.1021/jm00126a028.
A series of polyfluoro-3-quinolonecarboxylic acids have been synthesized and their in vitro antibacterial activity evaluated. The desired 7-(substituted amino) derivatives were prepared from the 5,6,7,8-tetrafluoroquinolone acids. Conversely, amine displacement occurred primarily at the 5-position when the ester was used. Structure-activity studies indicated that the antibacterial activity was greatest when the N-1 substituent was cyclopropyl and the 7-substituent was 4-methyl-1-piperazinyl. All 5-(substituted amino) derivatives showed poor in vitro activity.
