Proteomics and proteogenomics approaches for oral diseases.

Design and implementation of new biocompatible materials and achievements in the field of nanogenomics and nanoproteomics as well as in other related and allied sciences in the broader framework of translational and clinical nanomedicine are paving new avenues for nanodentistry. Classical dentistry is becoming more predictive, preventive, personalized, and participatory, providing the patients with a tailored and targeted treatment and handling of their diseases. Considering the global impact of the oral pathologies, being particularly heavy in underdeveloped and developing countries, it is mandatory from an ethical perspective to ensure a global oral health. Nanobiotechnologies play a major role in this ambitious goal. In this review, we will focus on the bioinformatics, nanogenomics, and nanoproteomics aspects of contemporary nanodentistry, emphasizing the urgent need for an integrated proteogenomics approach and addressing its clinical and translational implications and new future perspectives and scenarios.