Nanobiotechnology and Biophysics Laboratories (NBL), Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy; Nanoworld Institute Fondazione ELBA Nicolini (FEN), Pradalunga, Bergamo, Italy; School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Nanobiotechnology and Biophysics Laboratories (NBL), Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy; Nanoworld Institute Fondazione ELBA Nicolini (FEN), Pradalunga, Bergamo, Italy.
Adv Protein Chem Struct Biol. 2014;95:125-62. doi: 10.1016/B978-0-12-800453-1.00004-X.
Design and implementation of new biocompatible materials and achievements in the field of nanogenomics and nanoproteomics as well as in other related and allied sciences in the broader framework of translational and clinical nanomedicine are paving new avenues for nanodentistry. Classical dentistry is becoming more predictive, preventive, personalized, and participatory, providing the patients with a tailored and targeted treatment and handling of their diseases. Considering the global impact of the oral pathologies, being particularly heavy in underdeveloped and developing countries, it is mandatory from an ethical perspective to ensure a global oral health. Nanobiotechnologies play a major role in this ambitious goal. In this review, we will focus on the bioinformatics, nanogenomics, and nanoproteomics aspects of contemporary nanodentistry, emphasizing the urgent need for an integrated proteogenomics approach and addressing its clinical and translational implications and new future perspectives and scenarios.
新的生物相容性材料的设计与实现，以及在纳米基因组学和纳米蛋白质组学领域的成果，以及在转化和临床纳米医学更广泛框架内的其他相关和相关科学领域的成果，为纳米牙科开辟了新的途径。传统的牙科正变得更具预测性、预防性、个性化和参与性，为患者提供量身定制和针对性的治疗，并处理他们的疾病。考虑到口腔疾病的全球影响，特别是在不发达国家和发展中国家更为严重，从伦理角度来看，必须确保全球口腔健康。纳米生物技术在这一宏伟目标中发挥着重要作用。在这篇综述中，我们将重点关注当代纳米牙科的生物信息学、纳米基因组学和纳米蛋白质组学方面，强调迫切需要综合蛋白质组学方法，并解决其临床和转化意义以及新的未来前景和设想。
