Forensic Medicine Department, Ministry of Interior, Kuwait City, Kuwait.
Adv Protein Chem Struct Biol. 2014;95:283-315. doi: 10.1016/B978-0-12-800453-1.00009-9.
This report focuses on the application of different proteomic techniques in diagnosis and treatment of psychiatric disorders such as major depression, suicidal behavior, schizophrenia, and attention deficit/hyperactivity disorder (ADHD). Firstly, we briefly describe different analytic approaches that can be applied for the discovery of specific biomarkers for diagnosing the above disorders, as well as for monitoring the effect of their treatment. Secondly, we discussed the types of biomarkers in general used in biomedicine for characterizing different disorders and diseases. Next, the potential applications of these biomarkers for diagnosing and managing major depression, suicidal behavior, schizophrenia, and ADHD are discussed in details. Forensic aspects of these biomarkers for the above disorders are also considered. Finally, we discuss the potential of specific biomarkers for distinguishing between comorbid psychiatric disorders in clinical setup as well as their potential for understanding mechanisms underlying the disorders and in discovery of new treatment strategies.
本报告重点介绍了不同蛋白质组学技术在诊断和治疗精神疾病（如重度抑郁症、自杀行为、精神分裂症和注意缺陷多动障碍（ADHD））中的应用。首先，我们简要描述了可用于发现特定生物标志物以诊断上述疾病的不同分析方法，以及用于监测其治疗效果的方法。其次，我们讨论了在生物医学中一般用于表征不同疾病的生物标志物类型。接下来，详细讨论了这些生物标志物在诊断和管理重度抑郁症、自杀行为、精神分裂症和 ADHD 中的潜在应用。还考虑了这些生物标志物在上述疾病中的法医应用。最后，我们讨论了特定生物标志物在临床环境中区分共患精神疾病的潜力，以及它们在理解疾病机制和发现新治疗策略方面的潜力。
