Cancer Molecular Diagnostics, St. James's Hospital, Dublin, Ireland.
Cancer Molecular Diagnostics, St. James's Hospital, Dublin, Ireland.
Leuk Res. 2014 Aug;38(8):997-8. doi: 10.1016/j.leukres.2014.06.003. Epub 2014 Jun 12.
The classical myeloproliferative neoplasms (MPN) are comparatively uncommon in children and display a degree of mutational naivety if considering the high frequency of known MPN driver events observed in the corresponding adult diseases. Whole exome sequencing has unravelled much of the underlying molecular complexity of MPN in adult patients yet less is known of the pathogenetic mechanisms when these diseases occur in childhood. It is proposed that such methodological approaches will contribute significant insights into the molecular landscape of childhood MPN that may in turn impact on understanding the pathophysiology of disease in their adult counterparts.
经典的骨髓增殖性肿瘤（MPN）在儿童中较为罕见，如果考虑到在相应的成人疾病中观察到的已知 MPN 驱动事件的高频，那么其具有一定程度的突变幼稚性。全外显子组测序揭示了成年患者 MPN 中许多潜在的分子复杂性，但当这些疾病发生在儿童时，其发病机制知之甚少。有人提出，这种方法学方法将为儿童 MPN 的分子图谱提供重要的见解，这反过来又可能影响对其成人对应物疾病病理生理学的理解。
