99mTc-ECD单光子发射计算机断层扫描在儿童颅缝早闭治疗中的作用
Role of 99mTc-ECD SPECT in the management of children with craniosynostosis.
作者信息
Barik Mayadhar, Bajpai Minu, Das Rashmi Ranajn, Malhotra Arun, Panda Shasanka Shekhar, Sahoo Manas Kumar, Dwivedi Sadanand
机构信息
Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.
Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar 751019, India.
出版信息
Biomed Res Int. 2014;2014:172646. doi: 10.1155/2014/172646. Epub 2014 Apr 16.
PURPOSE OF THE REPORT
There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis.
MATERIALS AND METHODS
We prospectively analyzed a cohort of 85 patients with craniosynostosis from year 2007 to 2012. All patients underwent evaluation with (99m)Tc-ECD SPECT and the results were correlated with radiological and surgical findings.
RESULTS
(99m)Tc-ECD SPECT revealed regional perfusion abnormalities in the cerebral hemisphere corresponding to the fused sutures preoperatively that disappeared postoperatively in all the cases. Corresponding to this, the mean mental performance quotient (MPQ) increased significantly (P < 0.05) postoperatively only in those children with absent perfusion defect postoperatively.
CONCLUSIONS
Our study suggests that early surgery and release of craniosynostosis in patients with preoperative perfusion defects (absent on (99m)Tc-ECD SPECT study) are beneficial, as they lead to improved MPQ after surgery.
报告目的
关于各种成像方式与颅缝早闭临床发现之间相关性的数据匮乏。此外，尚无研究专门报道（99m）锝 - 乙撑双半胱氨酸（99m）Tc - ECD单光子发射计算机断层扫描（SPECT）在大量颅缝早闭患者中的作用。
材料与方法
我们前瞻性分析了2007年至2012年期间85例颅缝早闭患者的队列。所有患者均接受了（99m）Tc - ECD SPECT评估，并将结果与放射学和手术结果相关联。
结果
（99m）Tc - ECD SPECT显示术前大脑半球对应于融合缝线处的区域灌注异常，所有病例术后均消失。与此相应，仅在术后无灌注缺损的儿童中，平均智力表现商数（MPQ）术后显著升高（P < 0.05）。
结论
我们的研究表明，对于术前存在灌注缺损（在（99m）Tc - ECD SPECT研究中显示）的颅缝早闭患者，早期手术和松解有益，因为这会导致术后MPQ改善。
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