Abdelzaher Eman, Abdallah Dina Mohamed
Department of Pathology, Faculty of Medicine, University of Alexandria, Alexandria 21533, Egypt.
Biomed Res Int. 2014;2014:968794. doi: 10.1155/2014/968794. Epub 2014 Apr 30.
Meningiomas are common intracranial tumors. Recently, histogenetic and phenotypic similarities between meningiomas and mesotheliomas have been proposed. We were interested in whether these similarities are reflected on the immunohistochemical level, which would add new potentially diagnostic markers for meningiomas.
The expression of mesothelioma-related markers (D2-40, Calretinin, Keratin 5/6, WT1, and Methotheioma-Ab1) was investigated in 87 cases of meningiomas and compared to EMA expression.
73.6% of meningioma cases were grade I, 20.7% were grade II, and 5.7% were grade III. 83.9% of meningioma cases were classical and 16.1% had special nonmeningothelial features. D2-40 was expressed in 37.9% of cases and was significantly restricted to classical meningiomas. Calretinin and WT1 were negative while Keratin 5/6 and Mesothelioma-Ab1 were weakly expressed in classical variants (5.7% and 3.4%, resp.). EMA was consistently expressed in all cases. Its expression was significantly higher than that of mesothelioma-related markers; this held true also when D2-40 expression was considered separately.
Mesothelioma-related markers are not extensively expressed in meningiomas, a finding that argues against their proposed histogenetic and phenotypic similarities. Compared to EMA, the significantly lower expression of mesothelioma-related markers and their restricted expression to classical meningioma variants hamper their potential future use as diagnostic markers for meningioma.
脑膜瘤是常见的颅内肿瘤。最近，有人提出脑膜瘤与间皮瘤在组织发生和表型上存在相似性。我们感兴趣的是这些相似性是否在免疫组织化学水平上有所体现，这可能会为脑膜瘤增添新的潜在诊断标志物。
研究了87例脑膜瘤中间皮瘤相关标志物（D2-40、钙视网膜蛋白、细胞角蛋白5/6、WT1和间皮瘤-Ab1）的表达情况，并与EMA表达进行比较。
73.6%的脑膜瘤病例为I级，20.7%为II级，5.7%为III级。83.9%的脑膜瘤病例为经典型，16.1%具有特殊的非脑膜内皮特征。37.9%的病例表达D2-40，且明显仅限于经典脑膜瘤。钙视网膜蛋白和WT1为阴性，而细胞角蛋白5/6和间皮瘤-Ab1在经典型变体中弱表达（分别为5.7%和3.4%）。所有病例均持续表达EMA。其表达明显高于间皮瘤相关标志物；单独考虑D2-40表达时也是如此。
间皮瘤相关标志物在脑膜瘤中未广泛表达，这一发现与它们所提出的组织发生和表型相似性相悖。与EMA相比，间皮瘤相关标志物表达明显较低且仅限于经典脑膜瘤变体，这妨碍了它们未来作为脑膜瘤诊断标志物的潜在用途。
