5型磷酸二酯酶抑制剂他达拉非对大鼠控尿反射的影响。
Effects of phosphodiesterase type 5 inhibitor, tadalafil, on continence reflex in rats.
作者信息
Izumi Hideaki, Kaiho Yasuhiro, Miyazato Minoru, Kawamorita Naoki, Nakagawa Haruo, Arai Yoichi
机构信息
Department of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan.
出版信息
Int Urogynecol J. 2014 Dec;25(12):1721-7. doi: 10.1007/s00192-014-2453-3. Epub 2014 Jul 3.
INTRODUCTION AND HYPOTHESIS
Effects of tadalafil, a phosphodiesterase type 5 inhibitor, on the urethral continence reflex induced by sneezing were investigated.
METHODS
The amplitude of urethral pressure responses during sneezing (A-URS) and urethral baseline pressure (UBP) were measured in female rats using a microtransducer-tipped catheter. Sneeze leak-point pressure (S-LPP), defined as the lowest amount of pressure required to induce fluid leakage from the urethral orifice during sneezing, was measured in rats with stress urinary incontinence (SUI) induced by vaginal distension. Values were determined before and after tadalafil administration.
RESULTS
Tadalafil dose dependently and significantly decreased A-URS and S-LPP. At the highest dose tested (6.0 mg/kg), A-URS and S-LPP decreased from 49.7 to 32.3 and from 63.9 to 44.2 cmH2O, respectively, whereas UBP did not significantly change.
CONCLUSIONS
Tadalafil attenuated the sneeze-induced urethral continence reflex by relaxing the striated muscles of the external urethral sphincter.
引言与假设
研究了5型磷酸二酯酶抑制剂他达拉非对打喷嚏诱发的尿道控尿反射的影响。
方法
使用微传感器尖端导管测量雌性大鼠打喷嚏时尿道压力反应的幅度（A-URS）和尿道基线压力（UBP）。在阴道扩张诱导的压力性尿失禁（SUI）大鼠中，测量打喷嚏漏点压力（S-LPP），定义为打喷嚏时尿道外口引起液体泄漏所需的最低压力量。在给予他达拉非之前和之后测定数值。
结果
他达拉非剂量依赖性且显著降低A-URS和S-LPP。在测试的最高剂量（6.0mg/kg）下，A-URS和S-LPP分别从49.7降至32.3以及从63.9降至44.2cmH2O，而UBP没有显著变化。
结论
他达拉非通过放松尿道外括约肌的横纹肌减弱了打喷嚏诱发的尿道控尿反射。
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