Ivanets N N, Sysoeva V P, Kinkul'kina M A, Avdeeva T I
Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(5):4-11.
There are two points of view on the relation between anxiety and depression: they are comorbid diseases or they are symptoms of the same disease. This inconsistency complicates the diagnosis of anxiety and depressive disorders in clinical practice, in particular in elderly patients. We attempted to study the nosological structure of anxiety states in elderly patients and work out recommendations on differential diagnosis of anxiety disorders and depressions.
A main group included 80 elderly patients with anxiety disorders, 80 patients with anxious depression were enrolled in comparison group. These groups were selected on the basis of the primary diagnosis made before enrollment patients into the study.
After the detailed examination of patients with anxiety disorders, the diagnosis has been changed in 67.5% of patients. Symptoms of all patients with hypochondriac, somatisized and somatoform pain disorders were corresponded to atypical anxious depression. Duration and severity of psychogenic disorders of adaptation and acute reactions to stress were also corresponded to the diagnosis of depression. All patients with obsessive-compulsive disorders had typical symptoms of neurosis-like schizophrenia, these patients were excluded from the study. After the revision of diagnoses, the group with anxiety disorders comprised 26 patients and the group with depression increased up to 131 patients. A between-group comparison of clinical/anamnesis data showed that mean age of patients with depression (59.7 years) was significantly higher than that of patients with anxiety disorders (56 years). Levels of anxiety measured with the Hamilton scale (HAM-A) were similar in both groups. MADRS scores were significantly higher in the depression group (27.9) compared to patients with anxiety disorders (16.5).
The most frequent diagnoses that mask depression in elderly people are hypochondriac, somatisized and somatoform pain disorders as well as acute reactions to stress and disorders of adaptation. Somatoform autonomic dysfunction and agoraphobia are less frequent diagnoses. Clinical-psychopathological examination of elderly patients with these disorders requires a careful search for symptoms of a possible atypical depression. Definite diagnosis is necessary for adequate treatment.
关于焦虑与抑郁的关系存在两种观点:它们是共病,或者是同一疾病的症状。这种不一致使得临床实践中焦虑和抑郁障碍的诊断变得复杂,尤其是在老年患者中。我们试图研究老年患者焦虑状态的疾病分类结构,并制定焦虑症和抑郁症鉴别诊断的建议。
主要组包括80例患有焦虑症的老年患者,比较组纳入80例伴有焦虑的抑郁症患者。这些组是根据患者入组研究前做出的初步诊断选择的。
在对焦虑症患者进行详细检查后,67.5%的患者诊断发生了变化。所有疑病症、躯体化和躯体形式疼痛障碍患者的症状均符合非典型焦虑抑郁症。适应的心理性障碍和对压力的急性反应的持续时间和严重程度也符合抑郁症的诊断。所有强迫症患者都有类神经症样精神分裂症的典型症状,这些患者被排除在研究之外。诊断修订后,焦虑症组有26例患者,抑郁症组增加到131例患者。临床/病史数据的组间比较显示,抑郁症患者的平均年龄(59.7岁)显著高于焦虑症患者(56岁)。两组用汉密尔顿量表(HAM-A)测量的焦虑水平相似。抑郁症组的MADRS评分(27.9)显著高于焦虑症患者(16.5)。
在老年人中掩盖抑郁症的最常见诊断是疑病症、躯体化和躯体形式疼痛障碍以及对压力和适应障碍的急性反应。躯体形式自主神经功能障碍和广场恐惧症的诊断较少见。对患有这些疾病的老年患者进行临床心理病理学检查需要仔细寻找可能的非典型抑郁症症状。明确诊断对于适当治疗是必要的。