Kapliev A V, Kotieva I M
Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(5):42-5.
Changes in catecholamine pool (epinephrine, norepinephrine, dopamine) and 5-oxyindoles (serotonin, 5-oxyindolacetic acid) in the diencephalic structures were studied in 2, 15, 40 days of neurogenic pain syndrome development in rats with double-sided entrapment of N. ischiadicus. The main manifestations of monoamine diencephalic dysfunction in the period of neurogenic pain chronization were described: the reduction of catecholamine pool, most evident in the thalamus; absolute and relative serotonin increase (especially in the hypothalamus); "minimization" of thalamus monoamine potential and shift of diencephalic balance to the hypothalamic MA-ergic component domination. The possible mechanisms of the imbalance and its role in the deformation of noci-antinociceptive interaction in the neurogenic pain process are discussed.
在坐骨神经双侧受压的大鼠神经源性疼痛综合征发展的第2天、15天和40天，研究了间脑结构中儿茶酚胺池（肾上腺素、去甲肾上腺素、多巴胺）和5-羟吲哚（血清素、5-羟吲哚乙酸）的变化。描述了神经源性疼痛慢性期单胺间脑功能障碍的主要表现：儿茶酚胺池减少，在丘脑中最为明显；血清素绝对和相对增加（尤其是在下丘脑中）；丘脑单胺电位“最小化”，间脑平衡向以丘脑5-羟色胺能成分为主转变。讨论了这种失衡的可能机制及其在神经源性疼痛过程中伤害性-抗伤害性相互作用变形中的作用。
