Overton D A, Shen C F, Ke G Y, Gazdick L P
Department of Psychiatry, Temple University School of Medicine, Philadelphia, PA 19140.
Psychopharmacology (Berl). 1989;97(4):514-20. doi: 10.1007/BF00439557.
This study tested structural analogs of phencyclidine (PCP) using drug discrimination procedures to determine which analogs produced discriminable effects similar to those of PCP. It also tested the utility of multiple-drug discrimination training (PCP versus other drugs or saline) as a method for increasing the specificity produced by training. All discrimination training took place in two-lever operant compartments using FR-10 reinforcement of presses on the correct lever. During training, rats were required to concurrently discriminate PCP from one or more other drug conditions. Rats in group 1 discriminated PCP (lever 1) versus saline (lever 2). Rats in group 2 discriminated PCP (lever 1) versus saline, fentanyl, phenobarbital, amphetamine, or mescaline (lever 2). In both groups 1 and 2, the required discriminations were rapidly learned. The percentage of PCP choices and the ED50 doses obtained during tests for generalization did not differ significantly in groups 1 and 2. Drugs to which responding on the PCP lever generalized included 1-[1-(2-thienyl)cyclohexyl]piperidine, N-ethyl-1-phenylcyclohexylamine, 1-phenylcyclohexylamine, ketamine, 1-(1-phenylcyclohexyl)morpholine, 1-[1-(2-thienyl)cyclohexyl]morpholine, N,N-diethyl-1-phenylcyclohexylamine, N-(iso-propyl)-1-phenylcyclohexylamine, N-methyl-1-phenylcyclohexylamine, N-(n-propyl)-1-phenylcyclohexylamine, Dextrorphan, (dl)-N-allyl-N-normetazocine, N-N-dimethyl-1-phenylcyclohexylamine, N-(n-butyl)-1-phenylcyclohexylamine, 1-[1-(2-thienyl)cyclohexyl]pyrrolidine, and N-(s-butyl)-1-phenylcyclohexylamine, in agreement with previous reports. Rats in group 3 discriminated PCP (lever 1) versus saline, cyclazocine, dextrorphan, phenobarbital, or mescaline (lever 2).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究使用药物辨别程序对苯环己哌啶（PCP）的结构类似物进行测试，以确定哪些类似物会产生与PCP相似的可辨别效应。研究还测试了多药辨别训练（PCP与其他药物或生理盐水）作为一种提高训练特异性方法的效用。所有辨别训练均在双杠杆操作性实验箱中进行，对正确杠杆的按压采用固定比率10强化。训练期间，要求大鼠同时将PCP与一种或多种其他药物状态区分开来。第1组大鼠区分PCP（杠杆1）与生理盐水（杠杆2）。第2组大鼠区分PCP（杠杆1）与生理盐水、芬太尼、苯巴比妥、苯丙胺或三甲氧苯乙胺（杠杆2）。在第1组和第2组中，所需的辨别能力均很快学会。在泛化测试期间获得的PCP选择百分比和半数有效剂量在第1组和第2组中无显著差异。在PCP杠杆上产生反应的泛化药物包括1-[1-(2-噻吩基)环己基]哌啶、N-乙基-1-苯基环己胺、1-苯基环己胺、氯胺酮、1-(1-苯基环己基)吗啉、1-[1-(2-噻吩基)环己基]吗啉、N,N-二乙基-1-苯基环己胺、N-(异丙基)-1-苯基环己胺、N-甲基-1-苯基环己胺、N-(正丙基)-1-苯基环己胺、右啡烷、(外消旋)-N-烯丙基-N-去甲左啡诺、N-N-二甲基-1-苯基环己胺、N-(正丁基)-1-苯基环己胺、1-[1-(2-噻吩基)环己基]吡咯烷和N-(仲丁基)-1-苯基环己胺，这与之前的报道一致。第3组大鼠区分PCP（杠杆1）与生理盐水、环唑辛、右啡烷、苯巴比妥或三甲氧苯乙胺（杠杆2）。（摘要截断于250字）
