类 obscurin 蛋白 1 的免疫球蛋白样结构域 7 和 12 的溶液核磁共振结构有助于人类癌症蛋白质相互作用网络的结构覆盖。
Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
作者信息
Pulavarti Surya V S R K, Huang Yuanpeng J, Pederson Kari, Acton Thomas B, Xiao Rong, Everett John K, Prestegard James H, Montelione Gaetano T, Szyperski Thomas
机构信息
Department of Chemistry, The State University of New York at Buffalo and Northeast Structural Genomics Consortium, Buffalo, NY, 14260, USA.
出版信息
J Struct Funct Genomics. 2014 Dec;15(4):209-14. doi: 10.1007/s10969-014-9185-y. Epub 2014 Jul 3.
High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.
解析出人 obscurin 样蛋白 1 的免疫球蛋白样结构域 7 和 12 的高质量溶液核磁共振结构。这两个结构域的序列一致性为 30%，正如预期的那样，它们的结构相当相似。这些新结构有助于对人类癌症相关蛋白的结构覆盖。结构域 7 中 Arg 812 的突变会导致罕见的 3-M 综合征，且该位点位于预计参与蛋白质-蛋白质相互作用的表面区域。
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