Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA.
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W283-7. doi: 10.1093/nar/gkr311. Epub 2011 May 23.
We describe PredUs, an interactive web server for the prediction of protein-protein interfaces. Potential interfacial residues for a query protein are identified by 'mapping' contacts from known interfaces of the query protein's structural neighbors to surface residues of the query. We calculate a score for each residue to be interfacial with a support vector machine. Results can be visualized in a molecular viewer and a number of interactive features allow users to tailor a prediction to a particular hypothesis. The PredUs server is available at: http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:PredUs.
我们介绍了 PredUs，这是一个交互式网络服务器，用于预测蛋白质-蛋白质界面。通过将查询蛋白质的结构邻居的已知界面的接触“映射”到查询蛋白质的表面残基，来识别潜在的界面残基。我们使用支持向量机为每个要成为界面的残基计算得分。结果可以在分子查看器中可视化，并且许多交互式功能允许用户根据特定假设定制预测。PredUs 服务器可在以下网址获得：http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:PredUs。
