Pre-clinical optical imaging and MRI for drug development in Alzheimer's disease.
作者信息
Rotman Maarten, Snoeks Thomas J A, van der Weerd Louise
机构信息
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Drug Discov Today Technol. 2011 Summer;8(2-4):e117-25. doi: 10.1016/j.ddtec.2011.11.005.
Optical and magnetic resonance imaging have the potential to be complementary non-invasive imaging modalities. Yet without advances in imaging technologies and contrast agents both have short-comings that cannot be ignored. In this review we demonstrate the pre-clinical use of the two imaging techniques in Alzheimer's disease, including examples from recent applications and discuss what is needed to improve their applicability for drug discovery.:
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