Struhl K
Trends Biochem Sci. 1989 Apr;14(4):137-40. doi: 10.1016/0968-0004(89)90145-X.
Four distinct structural motifs have been proposed for the DNA-binding domains of eukaryotic transcriptional regulatory proteins; the helix-turn-helix, two kinds of zinc finger, and the leucine zipper. Within each structural motif, there are often families of related proteins that recognize similar DNA sequences and are conserved throughout the eukaryotic kingdom. However, the processes of transcriptional activation and repression appear to be independent of the specific type of protein-DNA interaction.
真核转录调节蛋白的DNA结合结构域已提出四种不同的结构基序；螺旋-转角-螺旋、两种锌指结构和亮氨酸拉链。在每个结构基序中，通常存在相关蛋白家族，它们识别相似的DNA序列并在整个真核生物界保守。然而，转录激活和抑制过程似乎独立于蛋白-DNA相互作用的具体类型。
