固相结合法合成吗啉基甘氨酸寡核苷酸模拟物。
Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics.
机构信息
Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia.
Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia ; Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia.
出版信息
Beilstein J Org Chem. 2014 May 20;10:1151-8. doi: 10.3762/bjoc.10.115. eCollection 2014.
Abstract
An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits.
摘要
已开发出一种有效的基于固相的吗啉甘氨酸寡核苷酸 (MorGly) 模拟物的肽合成 (SPPS)。所提出的策略包括一种新型的特别设计的不稳定连接基团，该基团包含草酰基残基和作为第一个亚基的 2-氨甲基吗啉核苷类似物。
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