非典型和典型抗精神病药物治疗急性精神病的起效时间。
Onset of action of atypical and typical antipsychotics in the treatment of acute psychosis.
作者信息
Mousavi Seyed Ghafur, Rostami Hamze, Sharbafchi Mohammad Reza, Boroujeni Atefeh Saeidi, Mahaki Behzad
机构信息
Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Psychiatry, Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Pharm Pract. 2013 Oct;2(4):138-44. doi: 10.4103/2279-042X.128142.
OBJECTIVE
Antipsychotic medications are the frontline treatment for the most psychotic disorders. The aim of this study is to compare the onset of action of the first and second generation antipsychotics and the rate of their side-effects in the treatment of acute psychosis.
METHODS
In a double-blind, controlled clinical trial, 40 acute psychotic patients were randomly allocated in four groups and treated with each of the four antipsychotics: olanzapine, risperidone, haloperidol or thiothixene. The onset of action of each drug was assessed by the Positive and Negative Symptoms Scale. The data were analyzed by Wilcoxon (Gehan) survival and Log Rank analysis, using SPSS version 20.0.
FINDINGS
Initial response was observed in 97.5% (N = 39) of subjects during 2 weeks of intervention. The mean time to the first response was 6.15 ± 2.9 days and this was significantly shorter for risperidone than others. The most common side-effects were sedation and drug induced Parkinsonism.
CONCLUSION
Risperidone represented shorter onset of action for the treatment of acute psychotic symptoms compared with olanzapine, haloperidol and thiothixene.
目的
抗精神病药物是大多数精神障碍的一线治疗药物。本研究旨在比较第一代和第二代抗精神病药物在治疗急性精神病时的起效时间及其副作用发生率。
方法
在一项双盲对照临床试验中，40名急性精神病患者被随机分为四组，分别接受四种抗精神病药物治疗：奥氮平、利培酮、氟哌啶醇或硫利达嗪。每种药物的起效时间通过阳性和阴性症状量表进行评估。使用SPSS 20.0软件，通过Wilcoxon（Gehan）生存分析和对数秩分析对数据进行分析。
结果
在干预的2周内，97.5%（N = 39）的受试者出现了初始反应。首次反应的平均时间为6.15±2.9天，利培酮的这一反应时间明显短于其他药物。最常见的副作用是镇静和药物性帕金森综合征。
结论
与奥氮平、氟哌啶醇和硫利达嗪相比，利培酮治疗急性精神病症状的起效时间更短。
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