Gerding P A, McLaughlin S A, Brightman A H, Essex-Sorlie D, Helper L C
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1989 May;50(5):624-8.
Intraocular pressure (IOP) was determined in right eyes of 20 healthy dogs after sodium hyaluronate (1%, n = 5), sodium chondroitin sulfate (4%) and sodium hyaluronate (3%, n = 5), hydroxypropyl methylcellulose (2%, n = 5), or balanced salt solution (control, n = 5) was injected into the anterior chamber. Applanation tonometry was used to measure IOP in both eyes of each dog for up to 168 hours. The 3 viscoelastic solutions resulted in an increased mean IOP by postinjection hours (PIH) 2; from PIH 12 until PIH 72, the IOP was significantly (P less than 0.001) lower than baseline. The control group did not have an increase in IOP at PIH 2; mean IOP decreased below baseline measurements within 2 hours and remained lower until PIH 72. Mean differences in IOP were not found among treated eyes (P = 0.50), and a significant interaction of any treated eyes in a group was not detected (P = 0.21). By PIH 168, the IOP approached baseline values in all groups.
在20只健康犬的右眼内注射透明质酸钠（1%，n = 5）、硫酸软骨素钠（4%）和透明质酸钠（3%，n = 5）、羟丙基甲基纤维素（2%，n = 5）或平衡盐溶液（对照组，n = 5）后，测定眼内压（IOP）。使用压平眼压计测量每只犬双眼的IOP，最长测量168小时。3种粘弹性溶液在注射后2小时导致平均IOP升高；从注射后12小时到72小时，IOP显著低于基线（P < 0.001）。对照组在注射后2小时IOP没有升高；平均IOP在2小时内降至基线测量值以下，并一直保持较低水平直到注射后72小时。各治疗组之间未发现IOP的平均差异（P = 0.50），且未检测到任何一组中各治疗组之间存在显著交互作用（P = 0.21）。到注射后168小时，所有组的IOP均接近基线值。
