Tintori Cristina, Brai Annalaura, Fallacara Anna Lucia, Fazi Roberta, Schenone Silvia, Botta Maurizio
Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Chimica e Tecnologie Farmaceutiche, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy.
Curr Opin Pharmacol. 2014 Oct;18:1-8. doi: 10.1016/j.coph.2014.06.005. Epub 2014 Jul 1.
Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein-protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein.
本文总结了两种开发抗艾滋病新药的新方法，每种方法都在抗HIV治疗中取得了重要发现。尽管高效抗逆转录病毒疗法（HAART）在降低死亡率方面取得了成功，但临床上耐药菌株仍不断出现，这凸显了开发下一代药物的重要性。蛋白质-蛋白质相互作用和人类细胞辅助因子是未来HIV研究的新靶点。本文描述了这两种新策略在过去几年中取得的最相关成果。
