School of Life and Health Sciences, Aston University, Birmingham, UK.
Eye (Lond). 2014 Sep;28(9):1041-52. doi: 10.1038/eye.2014.141. Epub 2014 Jul 4.
The quarter century since the foundation of the Royal College of Ophthalmologists has coincided with immense change in the subspecialty of medical retina, which has moved from being the province of a few dedicated enthusiasts to being an integral, core part of ophthalmology in every eye department. In age-related macular degeneration, there has been a move away from targeted, destructive laser therapy, dependent on fluorescein angiography to intravitreal injection therapy of anti-growth factor agents, largely guided by optical coherence tomography. As a result of these changes, ophthalmologists have witnessed a marked improvement in visual outcomes for their patients with wet age-related macular degeneration (AMD), while at the same time developing and enacting entirely novel ways of delivering care. In the field of diabetic retinopathy, this period also saw advances in laser technology and a move away from highly destructive laser photocoagulation treatment to gentler retinal laser treatments. The introduction of intravitreal therapies, both steroids and anti-growth factor agents, has further advanced the treatment of diabetic macular oedema. This era has also seen in the United Kingdom the introduction of a coordinated national diabetic retinopathy screening programme, which offers an increasing hope that the burden of blindness from diabetic eye disease can be lessened. Exciting future advances in retinal imaging, genetics, and pharmacology will allow us to further improve outcomes for our patients and for ophthalmologists specialising in medical retina, the future looks very exciting but increasingly busy.
自皇家眼科医学院成立以来的四分之一个世纪以来,医学视网膜这一分支学科发生了巨大的变化,已经从少数专注的热衷者的领域发展成为每个眼科部门不可或缺的核心部分。在年龄相关性黄斑变性方面,已经从依赖于荧光素血管造影的靶向、破坏性激光治疗转向抗生长因子药物的玻璃体内注射治疗,这在很大程度上受到光学相干断层扫描的指导。由于这些变化,眼科医生见证了湿性年龄相关性黄斑变性(AMD)患者的视力结果显著改善,同时也开发和实施了全新的护理方式。在糖尿病视网膜病变领域,这段时间还见证了激光技术的进步以及从高度破坏性的激光光凝治疗向更温和的视网膜激光治疗的转变。玻璃体内治疗药物(包括类固醇和抗生长因子药物)的引入进一步推进了糖尿病黄斑水肿的治疗。这一时期,英国还引入了协调一致的全国性糖尿病视网膜病变筛查计划,这为减轻糖尿病眼病导致的失明负担带来了越来越多的希望。视网膜成像、遗传学和药理学的未来激动人心的进步将使我们能够进一步改善患者的治疗效果,也使专注于医学视网膜的眼科医生的未来看起来非常令人兴奋,但也越来越忙碌。