[Biological availability of glycerol trinitrate after sublingual administration].
作者信息
Rietbrock N, Herling C, Muck B
机构信息
Abteilung für Klinische Pharmakologie des Klinikums, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
出版信息
Arzneimittelforschung. 1989 Feb;39(2):267-9.
PMID:2499342
Abstract
The relative bioavailability of a glyceryl trinitrate (GTN) spray (Nitro-Corangin Spray) compared to that of another GTN Spray was evaluated in 12 healthy male volunteers using an open, randomized cross-over design with two treatment phases. The parameters Cmax, tmax and AUC0-1 showed no statistically significant differences between the two treatments. It is concluded that the two GTN-Sprays may be considered bioequivalent.
摘要
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