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IL-7 和 TSLP 受体：一对冤家。

IL-7 and TSLP receptors: twisted sisters.

机构信息

NATIONAL INSTITUTES OF HEALTH NATIONAL CANCER INSTITUTE.

出版信息

Blood. 2014 Jul 3;124(1):4-5. doi: 10.1182/blood-2014-05-574327.

DOI:10.1182/blood-2014-05-574327
PMID:24993875
Abstract

In this issue of Blood, Shochat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP), resulting in a novel dimerization mechanism that drives acute lymphoblastic leukemias.

摘要

在本期《Blood》中，Shochat 等人报告了白细胞介素 7（IL-7）和胸腺基质淋巴细胞生成素（TSLP）受体的突变，导致一种新型二聚化机制，从而驱动急性淋巴细胞白血病。

相似文献

[1]
IL-7 and TSLP receptors: twisted sisters.

Blood. 2014-7-3

[2]
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias.

J Exp Med. 2011-5-2

[3]
Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.

Cell Mol Life Sci. 2013-4-27

[4]
Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.

Blood. 2014-5-1

[5]
Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2.

Blood. 2012-8-20

[6]
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Biochim Biophys Acta Biomembr. 2024-10

[7]
Genomic analysis drives tailored therapy in poor risk childhood leukemia.

Cancer Cell. 2012-8-14

[8]
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.

Nat Immunol. 2000-7

[9]
Towards precision medicine in childhood leukemia--insights from mutationally activated cytokine receptor pathways in acute lymphoblastic leukemia.

Cancer Lett. 2014-9-28

[10]
A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis.

Haematologica. 2016-4

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[2]
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[3]
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[4]
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