Francis A R, Shetty T K, Bhattacharya R K
Biochemistry Division, Bhabha Atomic Research Centre, Bambay, India.
Cancer Lett. 1989 Jun;45(3):177-82. doi: 10.1016/0304-3835(89)90074-8.
Five natural and two synthetic phenolic compounds were tested for their ability to suppress mutagenicity of aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium tester strain TA100. Caffeic acid and eugenol were observed to inhibit mutagenicity of both the carcinogens, while chlorogenic acid was effective in the case of AFB1 alone and ellagic acid and butylated hydroxytoluene were found to be antimutagenic only for MNNG. These differential activities of the phenolic compounds appeared to be due to their different modes of action towards direct and indirect acting carcinogens.
测试了五种天然酚类化合物和两种合成酚类化合物抑制黄曲霉毒素B1（AFB1）和N-甲基-N'-硝基-N-亚硝基胍（MNNG）对鼠伤寒沙门氏菌测试菌株TA100致突变性的能力。观察到咖啡酸和丁香酚可抑制这两种致癌物的致突变性，而绿原酸仅对AFB1有效，发现鞣花酸和丁基化羟基甲苯仅对MNNG具有抗诱变作用。酚类化合物的这些不同活性似乎是由于它们对直接和间接作用致癌物的不同作用方式所致。
