辅助锂盐治疗预防抑郁症合并人格障碍患者的自杀行为。
Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders.
作者信息
Rombold Felicitas, Lauterbach Eric, Felber Werner, Mueller-Oerlinghausen Bruno, Ahrens Bernd, Bronisch Thomas, Kilb Birgit, Lewitzka Ute, Richter Kneginja, Broocks Andreas, Heuser Isabella, Hohagen Fritz, Quante Arnim
机构信息
Department of Psychiatry and Psychotherapy, Charité - Campus Benjamin Franklin , Berlin , Germany.
出版信息
Int J Psychiatry Clin Pract. 2014 Oct;18(4):300-3. doi: 10.3109/13651501.2014.940052. Epub 2014 Jul 23.
OBJECTIVE
Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet.
METHODS
A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted.
RESULTS
Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention.
CONCLUSIONS
On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.
目的
患有重度抑郁症和人格障碍的患者有很高的自杀行为风险。锂剂对情感障碍患者具有抗自杀特性。锂剂在伴有共病性人格障碍的情感障碍患者中的抗自杀作用尚未得到研究。
方法
对前瞻性、安慰剂对照锂剂干预研究（N = 167）中患有抑郁症且伴有共病性人格障碍（PD）并近期有自杀未遂经历的患者亚样本（n = 19）进行事后分析。
结果
在整个研究过程中，锂剂组（n = 8）有3名患者、安慰剂组（n = 11）有2名患者出现自杀未遂。在安慰剂组和锂剂干预组之间未检测到与自杀行为相关的差异。
结论
基于小样本量，与没有共病性PD的情感障碍患者相比，在伴有共病性PD的患者中，锂剂似乎对自杀行为没有影响。
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