强直性脊柱炎与骨关节炎患者全髋关节置换术后静脉血栓栓塞的比较。
Comparison of venous thromboembolism after total hip arthroplasty between ankylosing spondylitis and osteoarthritis.
作者信息
Shi Dongquan, Xu Xingquan, Song Kai, Xu Zhihong, Dai Jin, Chen Dongyang, Jiang Qing
机构信息
The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu 210008, China ; Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210061, China.
出版信息
Biomed Res Int. 2014;2014:712895. doi: 10.1155/2014/712895. Epub 2014 Jun 4.
OBJECTIVE
Ankylosing spondylitis (AS), an inflammatory rheumatic disease, will gradually lead to severe hip joint dysfunction. Total hip arthroplasty is a useful method to improve patients' quality of life. The aim of this study was to compare the incidence and risk factors of deep vein thrombosis (DVT) between AS and hip osteoarthritis.
METHODS
In a retrospective study, a total of 149 subjects who underwent cementless THA were studied. Clinical data, biochemical data, and surgery-related data were measured between AS and OA groups.
RESULTS
The incidence of DVT in AS group was lower than that of OA group, although no significant difference was detected (P = 0.89). The patients of AS group were much younger (P < 0.0001) and thinner (P = 0.018) compared with those of OA group. AS patients had higher ejection fraction (EF) (P = 0.016), higher platelet counts (P < 0.0001), and lower hypertension rate (P = 0.0004). The values of APTT, PT, and INR in AS patients were higher than those in OA patients (all P < 0.0001). The values of D-dimer and APTT were both significantly higher in DVT subjects than those in non-DVT subjects.
CONCLUSION
AS patients potentially had a lower incidence of DVT compared with OA patients.
目的
强直性脊柱炎（AS）是一种炎症性风湿疾病，会逐渐导致严重的髋关节功能障碍。全髋关节置换术是改善患者生活质量的一种有效方法。本研究旨在比较AS患者与髋关节骨关节炎患者深静脉血栓形成（DVT）的发生率及危险因素。
方法
在一项回顾性研究中，共对149例行非骨水泥型全髋关节置换术的患者进行了研究。测量了AS组和骨关节炎（OA）组的临床数据、生化数据及手术相关数据。
结果
AS组DVT的发生率低于OA组，尽管差异无统计学意义（P = 0.89）。与OA组患者相比，AS组患者更年轻（P < 0.0001）且更瘦（P = 0.018）。AS患者的射血分数（EF）更高（P = 0.016）、血小板计数更高（P < 0.0001）且高血压发生率更低（P = 0.0004）。AS患者的活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）及国际标准化比值（INR）值均高于OA患者（均P < 0.0001）。DVT患者的D - 二聚体和APTT值均显著高于非DVT患者。
结论
与OA患者相比，AS患者发生DVT的可能性更低。
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