Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt, Germany.
Cell. 2014 Jul 3;158(1):11-2. doi: 10.1016/j.cell.2014.06.021.
It is of great therapeutic importance to understand why tumors relapse after the failure of therapies targeting oncogenes to which cancer cells are addicted. In this issue, Kapoor et al. and Shao et al. identify the transcriptional coactivator YAP1 as a central driver of compensation for the loss of K-Ras signaling in K-Ras-dependent cancers.
了解为什么针对癌细胞成瘾的致癌基因的治疗失败后肿瘤会复发，这具有重要的治疗意义。在本期杂志中，Kapoor 等人和 Shao 等人确定转录共激活因子 YAP1 是 K-Ras 依赖性癌症中 K-Ras 信号丢失补偿的核心驱动因素。
