Edlund Maria, Burström Lage, Hagberg Mats, Lundström Ronnie, Nilsson Tohr, Sandén Helena, Wastensson Gunilla
Department of Occupational and Environmental Medicine, Sahlgrenska School of Public Health and Community Medicine, University of Göteborg, Göteborg, Sweden,
Int Arch Occup Environ Health. 2015 Apr;88(3):305-10. doi: 10.1007/s00420-014-0959-0. Epub 2014 Jul 5.
The aim of the present study was to investigate the possible increase in hand tremor in relation to hand-arm vibration (HAV) exposure in a cohort of exposed and unexposed workers.
Participants were 178 male workers with or without exposure to HAV. The study is cross-sectional regarding the outcome of tremor and has a longitudinal design with respect to exposure. The dose of HAV exposure was collected via questionnaires and measurements at several follow-ups. The CATSYS Tremor Pen(®) was used for measuring postural tremor. Multiple linear regression methods were used to analyze associations between different tremor variables and HAV exposure, along with predictor variables with biological relevance.
There were no statistically significant associations between the different tremor variables and cumulative HAV or current exposure. Age was a statistically significant predictor of variation in tremor outcomes for three of the four tremor variables, whereas nicotine use was a statistically significant predictor of either left or right hand or both hands for all four tremor variables.
In the present study, there was no evidence of an exposure-response association between HAV exposure and measured postural tremor. Increase in age and nicotine use appeared to be the strongest predictors of tremor.
本研究旨在调查在一组暴露和未暴露于手部-手臂振动(HAV)的工人中,手部震颤可能因HAV暴露而增加的情况。
参与者为178名男性工人,有或无HAV暴露。关于震颤结果,该研究为横断面研究;关于暴露情况,则采用纵向设计。通过问卷调查和多次随访测量来收集HAV暴露剂量。使用CATSYS震颤笔(®)测量姿势性震颤。采用多元线性回归方法分析不同震颤变量与HAV暴露之间的关联,以及与具有生物学相关性的预测变量之间的关联。
不同震颤变量与累积HAV或当前暴露之间无统计学显著关联。年龄是四个震颤变量中三个变量震颤结果变化的统计学显著预测因素,而对于所有四个震颤变量,使用尼古丁是左手或右手或双手震颤的统计学显著预测因素。
在本研究中,没有证据表明HAV暴露与测量的姿势性震颤之间存在暴露-反应关联。年龄增长和使用尼古丁似乎是震颤的最强预测因素。