Tsujimoto M, Sugiyama M, Adachi H
Suntory Institute for Biomedical Research, Osaka, Japan.
Lymphokine Res. 1989 Summer;8(2):99-106.
Effect of interferon (IFN)s on fibroblast growth enhancing activity of tumor necrosis factor (TNF) was examined. IFN-gamma and -beta inhibited TNF-mediated growth stimulation of FS-4 cells. IFNs also inhibited dexamethasone (DEX)-mediated amplification of mitogenic activity of TNF. Significant inhibition was still demonstrable when IFN-gamma was added 2 days after treatment with TNF. On the other hand, no mitogenic activity of TNF was observed when cells were pretreated with IFN-gamma for 6h. These results suggested that interaction between TNF and IFN-gamma might play a role in modulation of some inflammatory processes in vivo.
研究了干扰素（IFN）对肿瘤坏死因子（TNF）成纤维细胞生长增强活性的影响。γ-干扰素和β-干扰素抑制了TNF介导的FS-4细胞生长刺激。IFN也抑制了地塞米松（DEX）介导的TNF促有丝分裂活性的增强。在用TNF处理2天后添加γ-干扰素时，仍可观察到显著抑制作用。另一方面，当细胞用γ-干扰素预处理6小时时，未观察到TNF的促有丝分裂活性。这些结果表明，TNF与γ-干扰素之间的相互作用可能在体内某些炎症过程的调节中起作用。
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