Jackson Gary, Gerard Catherine, Minko Nikolai, Parsotam Nirasha
Health Quality and Safety Commission, PO Box 25496, Wellington 6146, New Zealand.
N Z Med J. 2014 Jun 20;127(1396):67-78.
To examine the variation in the dispensing of antipsychotic and benzodiazepine medicines in the elderly (aged 65+) across New Zealand.
Data drawn from the New Zealand Pharmaceutical Collection for the New Zealand Atlas of Healthcare Variation was used to establish a regression model to examine dispensing rates by age, gender, district health board (DHB) of domicile and aged residential care usage rates over a 4 year period 2008/09 to 2011/12.
On average 24 per 1000 people aged 65+ in New Zealand were dispensed an antipsychotic in any given quarter. Benzodiazepine dispensing rates were even higher, at 109 per 1000 aged 65+. Both rates climbed steeply with age, were higher in females, and had a 1.6 to 1.8 fold variation across DHBs. Rates did not vary significantly with rest home and private hospital residential care usage, but antipsychotic rates appeared related to the use of psychogeriatric and dementia beds.
Given the evident harms associated with the use of antipsychotic and benzodiazepine medicines in the elderly, and the relatively poor efficacy of antipsychotics in dementia care, prescribing of these medicines should be reassessed. DHBs should examine the causes of the high rates in their area and design interventions to reduce the rates.
研究新西兰65岁及以上老年人中抗精神病药物和苯二氮䓬类药物的配药差异。
利用从《新西兰医疗保健差异地图集》的新西兰药品收集数据建立回归模型,以研究2008/09年至2011/12年这4年期间按年龄、性别、居住地区卫生委员会(DHB)和老年住宅护理使用率划分的配药率。
在新西兰,每1000名65岁及以上的老年人中,平均每季度有24人配到抗精神病药物。苯二氮䓬类药物的配药率更高,每1000名65岁及以上的老年人中有109人。这两种配药率都随着年龄的增长而急剧上升,女性的配药率更高,并且在各地区卫生委员会之间存在1.6至1.8倍的差异。配药率与养老院和私立医院的住院护理使用率没有显著差异,但抗精神病药物的配药率似乎与老年精神病科和痴呆症病床的使用有关。
鉴于老年人使用抗精神病药物和苯二氮䓬类药物存在明显危害,且抗精神病药物在痴呆症护理中的疗效相对较差,应重新评估这些药物的处方。各地区卫生委员会应调查本地区高配药率的原因,并设计干预措施以降低配药率。